Cancer is a process in which cancer cells and cancer specific T cells of the autoimmune system compete and play against each other. In the field of tumor prevention and treatment, commonly used detection techniques mainly focus on detecting indicators related to tumor tissue and cancer cells (such as genetic testing, circulating tumor cell testing, and ctDNA testing). Traditional peptide antigen or MHC tetramer techniques can only detect T cells that can recognize several specific antigen peptides, and the types of T cells detected are limited Incomplete and inaccurate (many patients do not have specific T cells in their bodies that recognize the corresponding peptides).and Lack of comprehensive and accurate direct detection methods for cancer cell specific T cells that specifically recognize and kill cancer cells in the human immune system。The number and activity of this type of T cells are closely related to the efficacy of tumor immunotherapy and the probability of recurrence in patients after treatment. Generally speaking, the more cancer specific T cells there are, the stronger their ability to recognize and kill cancer (the better the patient's treatment and prognosis will be), and vice versa Clinical trials are currently being conducted on lung cancer and esophageal cancer patients undergoing PD-1 antibody immunotherapy.
Ersheng has pioneered the development of specific T cell detection technology, which involves co culturing PBMCs isolated from peripheral blood of cancer patients with detection reagents from Ersheng Biopharmaceutical Co., Ltd. and using flow cytometry to detect the number or ratio of specific T cells.
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